Mechanisms and clinical correlates of sperm DNA damage
نویسندگان
چکیده
منابع مشابه
Mechanisms and clinical correlates of sperm DNA damage.
Among the different DNA anomalies that can be present in the male gamete, DNA fragmentation is the most frequent, particularly in infertile subjects. There is now consistent evidence that a sperm containing fragmented DNA can be alive, motile, morphologically normal and able to fertilize an oocyte. There is also evidence that the oocyte is able to repair DNA damage; however, the extent of this ...
متن کاملOxidative Damage to Sperm DNA: Clinical Implications
Background: Sperm DNA is susceptible to oxidative damage due to intrinsic and extrinsic factors which cause oxidative stress and due to limited DNA damage detection and repair mechanism. Reactive oxygen species (ROS) are the chief cause of sperm DNA damage. So, this study was planned to assess oxidative stress levels and correlate with sperm DNA damage. Material and Method: The study included 3...
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tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Agarwal et al. in their most recent paper (1) propose a clinical guideline on the use of sperm DNA damage testing in infertility treatment. This guideline is extremely relevant for fertility specialists and further insight into the topic is in high demand as the debate regarding the role of DNA damage testing is still...
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BACKGROUND Sperm DNA damage shows great promise as a biomarker of infertility. The study aim is to determine the usefulness of DNA fragmentation (DF), including modified bases (MB), to predict assisted reproduction treatment (ART) outcomes. METHODS DF in 360 couples (230 IVF and 130 ICSI) was measured by the alkaline Comet assay in semen and in sperm following density gradient centrifugation ...
متن کاملSperm DNA damage and its relation with leukocyte DNA damage.
DNA fragmentation in human sperm has been related to endogenous and exogenous factors. Exogenous factors can also affect leukocyte DNA integrity. This study evaluated the relation between sperm DNA damage and leukocyte DNA integrity, as a predictor of exogenous factors. DNA damage in the sperm and leukocytes of 41 individuals undergoing ICSI were measured by Comet assay. In addition, sperm chro...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2011
ISSN: 1008-682X,1745-7262
DOI: 10.1038/aja.2011.59